Cases were defined as having >0.75 diopters of corneal astigmatism. Methods A meta-analysis of genome-wide association studies (GWASs) of corneal astigmatism undertaken for 14 European ancestry (n=22,250) and 8 Asian ancestry (n=9,120) cohorts was performed by the Consortium for Refractive Error and Myopia. Purpose To identify genes and genetic markers associated with corneal astigmatism. Subsequent gene-based and gene-set analyses of the meta-analyzed results of European ancestry cohorts we. Methods: A meta-analysis of genome-wide association studies (GWASs) of corneal astigmatism undertaken for 14 European ancestry (n=22,250) and 8 Asian ancestry (n=9,120) cohorts was performed by the Consortium for Refractive Error and Myopia.
Xie, Jing Wang, Ya Xing Hess, Moritz Nickels, Stefan Lackner, Karl J. Fan, Qiao Yazar, Seyhan Williams, Katie M.
Köttgen, Anna Albrecht, Eva Teumer, Alexander Vitart, Veronique Krumsiek, Jan Hundertmark, Claudia Pistis, Giorgio Ruggiero, Daniela O'Seaghdha, Conall M Haller, Toomas Yang, Qiong Tanaka, Toshiko Johnson, Andrew D Kutalik, Zoltán Smith, Albert V Shi, Julia Struchalin, Maksim Middelberg, Rita P S Brown, Morris J Gaffo, Angelo L Pirastu, Nicola Li, Guo Hayward, Caroline Zemunik, Tatijana Huffman, Jennifer Yengo, Loic Zhao, Jing Hua Demirkan, Ayse Feitosa, Mary F Liu, Xuan Malerba, Giovanni Lopez, Lorna M van der Harst, Pim Li, Xinzhong Kleber, Marcus E Hicks, Andrew A Nolte, Ilja M Johansson, Asa Murgia, Federico Bakker, Stephan J L Lagou, Vasiliki Bruinenberg, Marcel Stolk, Ronald P Penninx, Brenda W Mateo Leach, Irene van Gilst, Wiek H Hillege, Hans L Wolffenbuttel, Bruce H R Snieder, Harold Navis, GerjanĪ genome-wide association study of corneal astigmatism: The CREAM Consortium
By combining data from >140,000 individuals of European ancestry within the Global Urate Genetics Consortium (GUGC), we identified and replicated 28 genome-wide significant loci in association with Gieger, C.Įlevated serum urate concentrations can cause gout, a prevalent and painful inflammatory arthritis. Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
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